Protein Engineering (solubility / expression / stability / function)

A custom design campaign to improve a difficult protein — solubility, E. coli expression, thermostability, or activity — combining structure-guided rational design (AlphaFold + aggregation/solubility analysis), interface-safe generative redesign (ProteinMPNN), and cysteine/surface engineering. You supply the target and the problem; we return a ranked, fold-validated variant panel with rationale, codon-optimized DNA for the top constructs, and an experimental plan. List price: $1499. Final pricing depends on input size and scope — request a quote. Research use only; computational predictions require experimental validation. Methodology & tool catalog: https://nexteln.com/services/protein_engineering