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Murine Leukemia Virus (MLV) Pseudotyped with SARS-CoV-2 Spike Glycoprotein
Catalog #:
EG-345
Qty:
Product Name
Murine Leukemia Virus (MLV)Pseudotyped with SARS-CoV-2 Spike Glycoprotein, HexaPro Stabilized Trimer
Description
Murine leukemia retrovirus (MLV) particles pseudotyped with SARS‑CoV‑2 spike glycoprotein, with hexaPro mutations so the surface protein antigenically optimal pre-fusion conformation, produced and purified from HEK 293 cells
Mutations
Furin site RRAR mutated to GSAS; HexaPro mutations (K986P, V987P, F817P, A892P, A899P and A942P) to ensure the S glycoprotein remains in an antigenically optimal pre-fusion conformation
Source
HEK293T cells
Reporter
EGFP
Application
Screening of SARS‑CoV‑2 neutralizing antibodies
Assessment of vaccine efficacy
Titer
> 1 X 10
7
RFU/ml or > 1 X 10
5
TU/ml
Shipping
Dry ice
Storage
-80 oC
References
Murine Leukemia Virus (MLV)-based Coronavirus Spike-pseudotyped Particle Production and Infection. Bio Protoc. 2016 Dec 5; 6(23): e2035.
doi:10.21769/BioProtoc.2035
Retroviral vectors pseudotyped with severe acute respiratory syndrome coronavirus S protein
doi: 10.1128/JVI.78.17.9007-9015.2004
. PubMed: 15308697
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