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Lentivirus Pseudotyped with SARS-CoV-2 Spike Glycoprotein, HexaPro Stabilized Trimer
Catalog #:
EG-341
Please Choose:
Size
100 µl ( $798.00 )
1 ml ( $5,000.00 )
Qty:
Product Name
Lentivirus Pseudotyped with SARS-CoV-2 Spike Glycoprotein, HexaPro Stabilized Trimer
Description
Lentivirus particles pseudotyped with SARS‑CoV‑2 spike glycoprotein, with hexaPro mutations so the surface protein antigenically optimal pre-fusion conformation, produced and purified from HEK 293 cells
Mutations
Furin site RRAR mutated to GSAS; HexaPro mutations (K986P, V987P, F817P, A892P, A899P and A942P) to ensure the S glycoprotein remains in an antigenically optimal pre-fusion conformation
Source
HEK293T cells
Reporter
EGFP
Application
Screening of SARS‑CoV‑2 neutralizing antibodies
Assessment of vaccine efficacy
Titer
> 1 X 10
7
RFU/ml or > 1 X 10
5
TU/ml
Shipping
Dry ice
Storage
-80 oC
References
Efective screening of SARS‑CoV‑2 neutralizing antibodies in patient serum using lentivirus particles pseudotyped with SARS‑CoV‑2 spike glycoprotein. Sci Rep 10, 19076 (2020).
doi:10.1038/s41598-020-76135-w
Prospective Mapping of Viral Mutations that Escape Antibodies Used to Treat COVID-19. Science. 371 (2020): 850-854.
doi: 10.1126/science.abf9302
. PubMed: 33495308.
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