E coli nucleoid-associated protein Fis

Fis, also known as factor-for-inversion stimulation protein, Hin recombinational enhancer-binding protein, is a homodimeric nucleoid-associated protein. It has the following cellular functions:

• Activates ribosomal RNA transcription, as well other genes.
• Plays a direct role in upstream activation of rRNA promoters.
• Binds to a recombinational enhancer sequence that is required to stimulate hin-mediated DNA inversion.
• Prevents initiation of DNA replication from oriC.

in vitro recombination assay