Cas13A (CRISPR Associated Protein 13a)

Cas13a is class 2 type VI CRISPR-Cas system RNA-guided RNA endonuclease. Cas13a possess both RNA recognition and cleavage activities and cleaves RNA through conserved basic residues within its two HEPN domains . Upon recognition Cas13a induces collateral cleavage of nearby non-targeted RNAs nonspecifically.

LwCas13a, LwaCas13a, LwC2c2, EndoRNase, CRISPR-associated endoribonuclease Cas13a

• Targeted RNA knockdown
• RNA editing
• Nucleic acid detection

~ 95% as determined by SDS-PAGE