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Human Protein Kinase Alpha, PKA, C alpha, cAMP-dependent protein kinase catalytic subunit alpha isoform 1
"PKA C-alpha, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase catalytic subunit alpha, isoform 1, protein kinase A catalytic subunit"

Catalog #: RP-7203


Product Type: Protein Kinase

Size: 1 mg


$495.00

Qty:

  Background  
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq].


  Description  
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed


  Product Information  

 Source: E. coli
 Purity: >95% by SDS-PAGE analysis
 Purification Method: FPLC
 

  Gene/Protein Information  

 Gene ID: 5566 NCBI Link
 Gene Name: protein kinase, cAMP-dependent, catalytic, alpha
 Gene Symbol: PRKACA
 Gene Name Synonyms: PKACA
 NCBI Acc#: NM_002730, NM_207518, NP_002721, NP_997401
 HGNC#: 5566
 Chromosomal Location: 19p13.1
 


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