Product Name: p53 Lentivirus
Gene Description:
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Function of p53:
Acts as a tumor suppressor in many tumor types;
Induces growth arrest or apoptosis depending on the physiological circumstances and cell type.
Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by ontrolling a set of genes required for this process.
One of the activated genes is an inhibitor of cyclin-dependent kinases.
Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Implicated in Notch signaling cross-over.
Gene Name: TP53
Gene Alias: p53; LFS1; TRP53; FLJ92943; TP53
GeneBank Number: NP_000537; NM_000546
Titer: 1X107 TU/ml
Size: 200 µl
Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol
240-454-9768
