Catalog #: EG-1005
Human apurinic/apyrimidinic (AP) endonuclease, APE 1, also known as HAP 1 or Ref-1, is a homolog of Escherichia coli exonuclease III. APE1 acts as an AP lyase by hydrolyzing the phosphodiester backbone at the 5′ end of an apurinic (AP) site, generating a single-strand DNA break in the DNA duplex and leaving 3′-hydroxyl and 5′-deoxyribose phosphate termini. It is reported that APE 1 may also exhibit weak DNA 3′-diesterase, 3′ to 5′ exonuclease and RNase H activities.
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